Endocrine Abstracts

The present study was undertaken to determine morphological and biochemical characteristics of GH-producing tumor. We collected consecutively 15 patients with acromegaly, and they were 6 males and 9 females with the ages of 58.5±9.9 years. As for tumor size, 7 patients had macroadenoma, 5 had microadenoma and three had empty sella with some atypical expansions. Only 3 patients had intrasellar tumor and 2 patients had empty sella in MRI finding. Other 10 patients had atypi...

Introduction: Anaplastic thyroid carcinoma (ATC) carries an extremely poor prognosis. The reported median survival time is 3-9 months and one year survival rate is 18-20%. Here we report 4 cases of ATC.Case reports: Case 1: An 82 year-old female presented with rapidly progressive anterior neck swelling. She underwent hemi-thyroidectomy and D1 dissection. Pathological diagnosis was ATC, T4aN0. External beam radiotherapy (EBRT) to the whole neck was admini...

Background: Accurate intraoperative localization of primary and metastatic pancreatic neuroendocrine tumors (pNETs) is challenging, and molecularly driven fluorescence-guided surgery could significantly improve surgical outcomes with given the overexpression of somatostatin receptor subtype-2 (SSTR2). We developed an optimized SSTR2-targeted fluorescent agent, MMC(FNIR-Tag)-TOC, which expressed excellent targeting specificity and pharmacokinetics, as the lead compound for clin...

Background: Neuroendocrine tumors (NETs) are increasing in incidence and prevalence. Small intestine, rectum, pancreas and appendix are the most common enteric sites of NETs, and when identified early, surgical resection can be curative. We hypothesized that observed increases in incidence and prevalence of NETs are primarily driven by earlier detection of loco-regional tumors. In turn, increases in incidence of early-stage tumors is associated with increases in resection and ...